Keith A Josephs Selected Research

Synucleinopathies

12/2019	Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy.
10/2019	Progressive supranuclear palsy is not associated with neurogenic orthostatic hypotension.
9/2008	Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy?
10/2004	Apolipoprotein E epsilon 4 is a determinant for Alzheimer-type pathologic features in tauopathies, synucleinopathies, and frontotemporal degeneration.

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Keith A Josephs Research Topics

Disease

41	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 08/2022 - 01/2004
38	Alzheimer Disease (Alzheimer's Disease) 06/2022 - 04/2007
35	Frontotemporal Dementia (Semantic Dementia) 02/2022 - 10/2003
34	Atrophy 06/2022 - 04/2005
27	Dementia (Dementias) 08/2022 - 09/2003
25	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022 - 10/2002
21	Parkinsonian Disorders (Parkinsonism) 02/2022 - 08/2002
18	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 10/2004
14	Tauopathies 01/2022 - 10/2004
13	Corticobasal Degeneration 06/2022 - 10/2003
11	Cognitive Dysfunction 02/2022 - 06/2004
10	Motor Neuron Disease (Primary Lateral Sclerosis) 11/2022 - 07/2005
9	Primary Progressive Aphasia 12/2019 - 05/2010
8	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2022 - 11/2009
8	Parkinson Disease (Parkinson's Disease) 12/2019 - 09/2005
7	Aphasia (Dysphasia) 02/2022 - 12/2013
7	Apraxias (Dyspraxia) 09/2020 - 12/2008
7	Tremor (Tremors) 04/2013 - 09/2003
6	Hippocampal Sclerosis 01/2020 - 01/2004
4	Psychotic Disorders (Schizoaffective Disorder) 01/2022 - 09/2003
4	Pick Disease of the Brain (Pick's Disease) 11/2020 - 09/2005
4	Sarcoma (Soft Tissue Sarcoma) 01/2020 - 07/2010
4	Synucleinopathies 12/2019 - 10/2004
4	Amyloid Plaque 01/2019 - 01/2003
4	Neoplasms (Cancer) 05/2016 - 06/2004
4	Multiple System Atrophy 09/2008 - 04/2005
3	Hallucinations (Hallucination) 02/2022 - 12/2015
3	Lewy Body Disease (Lewy Body Dementia) 01/2021 - 09/2008
3	Disease Progression 01/2020 - 07/2008
3	Brain Diseases (Brain Disorder) 02/2012 - 06/2004
2	Vascular Diseases (Vascular Disease) 01/2022 - 06/2004
2	Proteostasis Deficiencies 01/2020 - 12/2013
2	Memory Disorders (Memory Loss) 01/2019 - 01/2014
2	Language Disorders (Language Disorder) 11/2014 - 03/2014
2	Dystonia (Limb Dystonia) 01/2013 - 10/2009
2	Myoclonus (Nocturnal Myoclonus) 09/2011 - 09/2007
2	Gliosis 12/2008 - 04/2005
2	Cerebellar Ataxia (Dysmetria) 09/2008 - 12/2004
1	Fasciculation (Fasciculations) 11/2022
1	REM Sleep Behavior Disorder 02/2022
1	Anomia (Dysnomia) 01/2021
1	Paraparesis 01/2021
1	Orthostatic Hypotension (Postural Hypotension) 10/2019
1	Amnesia (Dissociative Amnesia) 01/2019
1	Meningioma (Meningiomas) 12/2017
1	Seizures (Absence Seizure) 05/2016

Drug/Important Bio-Agent (IBA)

34	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2022 - 08/2008
26	Amyloid (Amyloid Fibrils)IBA 01/2022 - 03/2011
25	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2004
20	Biomarkers (Surrogate Marker)IBA 06/2022 - 07/2008
18	UbiquitinIBA 08/2022 - 01/2004
15	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2022 - 01/2016
15	ProgranulinsIBA 01/2018 - 11/2006
13	Apolipoproteins E (ApoE)IBA 06/2022 - 01/2003
13	Levodopa (L Dopa)FDA LinkGeneric 02/2022 - 10/2002
10	ApolipoproteinsIBA 06/2022 - 09/2003
10	Amyloid beta-PeptidesIBA 01/2021 - 02/2008
7	SynucleinsIBA 01/2022 - 02/2007
7	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2020 - 12/2013
7	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 09/2017 - 12/2008
6	Biological ProductsIBA 01/2021 - 01/2004
6	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2021 - 01/2010
6	alpha-SynucleinIBA 01/2017 - 08/2002
5	tau Proteins (tau Protein)IBA 01/2017 - 01/2004
5	DNA (Deoxyribonucleic Acid)IBA 09/2013 - 01/2003
4	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2017
4	Dopamine Agonists (Dopamine Agonist)IBA 12/2010 - 09/2005
3	Protein Isoforms (Isoforms)IBA 01/2022 - 10/2007
3	N 30IBA 01/2021 - 01/2009
3	LigandsIBA 01/2019 - 01/2017
3	SteroidsIBA 05/2016 - 06/2004
3	Pharmaceutical PreparationsIBA 12/2015 - 09/2007
3	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 06/2011 - 09/2007
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 03/2011
2	DipeptidesIBA 10/2019 - 01/2017
2	Complement System Proteins (Complement)IBA 01/2019 - 07/2010
2	Dopamine (Intropin)FDA LinkGeneric 07/2017 - 04/2013
2	Amino Acids FDA Link 08/2015 - 11/2011
2	Messenger RNA (mRNA)IBA 09/2013 - 10/2011
2	MicroRNAs (MicroRNA)IBA 10/2011 - 12/2008
2	AutoantibodiesIBA 06/2011 - 10/2010
2	Cholinergic ReceptorsIBA 10/2010 - 09/2007
1	IronIBA 01/2022
1	Antipsychotic Agents (Antipsychotics)IBA 01/2022
1	Carrier Proteins (Binding Protein)IBA 01/2022
1	Adenosine Monophosphate (AMP)IBA 01/2021
1	Dopamine Receptors (Dopamine Receptor)IBA 09/2020
1	2- carbomethoxy- 8- (3- fluoropropyl)- 3- (4- iodophenyl)tropaneIBA 09/2020
1	ioflupaneIBA 09/2020
1	aspartyl- arginyl- valyl- tyrosyl- isoleucyl- histidyl- prolyl- phenylalanyl- histidyl- leucyl- valyl- isoleucyl- histidine (hTDP)IBA 05/2020
1	Prostaglandins FIBA 01/2020
1	hydroxide ionIBA 10/2019
1	TeaIBA 01/2019
1	HLA-DQA2 antigenIBA 01/2019
1	Apolipoprotein E4IBA 01/2017
1	PrionsIBA 04/2016

Therapy/Procedure

9	Therapeutics 11/2020 - 09/2005
2	Immunotherapy 06/2011 - 10/2010
1	Denervation 11/2022
1	Precision Medicine 12/2019